| Microtubule-associated protein tau is essential for long-term depression in the hippocampus T Kimura, DJ Whitcomb, J Jo, P Regan, T Piers, S Heo, C Brown, ... Philosophical Transactions of the Royal Society B: Biological Sciences 369 …, 2014 | 336 | 2014 |
| Tau phosphorylation at serine 396 residue is required for hippocampal LTD P Regan, T Piers, JH Yi, DH Kim, S Huh, SJ Park, JH Ryu, DJ Whitcomb, ... Journal of Neuroscience 35 (12), 4804-4812, 2015 | 207 | 2015 |
| Human induced pluripotent stem cell-derived microglia-like cells harboring TREM2 missense mutations show specific deficits in phagocytosis P Garcia-Reitboeck, A Phillips, TM Piers, C Villegas-Llerena, M Butler, ... Cell Reports 24 (9), 2300-2311, 2018 | 143 | 2018 |
| Acute stress causes rapid synaptic insertion of Ca2+-permeable AMPA receptors to facilitate long-term potentiation in the hippocampus G Whitehead, J Jo, EL Hogg, T Piers, DH Kim, G Seaton, H Seok, ... Brain 136 (12), 3753-3765, 2013 | 126 | 2013 |
| The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans X Xiang, TM Piers, B Wefers, K Zhu, A Mallach, B Brunner, G Kleinberger, ... Molecular neurodegeneration 13, 1-14, 2018 | 115 | 2018 |
| Intracellular oligomeric amyloid-beta rapidly regulates GluA1 subunit of AMPA receptor in the hippocampus DJ Whitcomb, EL Hogg, P Regan, T Piers, P Narayan, G Whitehead, ... Scientific reports 5 (1), 10934, 2015 | 108 | 2015 |
| A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC‐derived microglia TM Piers, K Cosker, A Mallach, GT Johnson, R Guerreiro, J Hardy, ... The FASEB Journal 34 (2), 2436, 2020 | 101 | 2020 |
| Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions W Liu, O Taso, R Wang, S Bayram, AC Graham, P Garcia-Reitboeck, ... Human molecular genetics 29 (19), 3224-3248, 2020 | 100 | 2020 |
| Translational concepts of mGluR5 in synaptic diseases of the brain TM Piers, DH Kim, BC Kim, P Regan, DJ Whitcomb, K Cho Frontiers in pharmacology 3, 199, 2012 | 86 | 2012 |
| Safinamide and flecainide protect axons and reduce microglial activation in models of multiple sclerosis D Morsali, D Bechtold, W Lee, S Chauhdry, U Palchaudhuri, P Hassoon, ... Brain 136 (4), 1067-1082, 2013 | 84 | 2013 |
| A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene N Magusali, AC Graham, TM Piers, P Panichnantakul, U Yaman, M Shoai, ... Brain 144 (12), 3727-3741, 2021 | 79 | 2021 |
| Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease K Hirano, TM Piers, KL Searle, ND Miller, AR Rutter, PF Chapman Life sciences 84 (15-16), 558-562, 2009 | 70 | 2009 |
| Modelling microglial function with induced pluripotent stem cells: an update JM Pocock, TM Piers Nature Reviews Neuroscience 19 (8), 445-452, 2018 | 59 | 2018 |
| Neuroprotection by safinamide in the 6‐hydroxydopamine model of P arkinson's disease M Sadeghian, G Mullali, JM Pocock, T Piers, A Roach, KJ Smith Neuropathology and applied neurobiology 42 (5), 423-435, 2016 | 50 | 2016 |
| Microglial signalling pathway deficits associated with the patient derived R47H TREM2 variants linked to AD indicate inability to activate inflammasome K Cosker, A Mallach, J Limaye, TM Piers, J Staddon, SJ Neame, J Hardy, ... Scientific Reports 11 (1), 13316, 2021 | 45 | 2021 |
| Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection TM Piers, SJ Heales, JM Pocock Neuroscience letters 505 (2), 140-145, 2011 | 38 | 2011 |
| Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus JH Yi, C Brown, G Whitehead, T Piers, YS Lee, CM Perez, P Regan, ... Pharmacological Research 121, 42-51, 2017 | 34 | 2017 |
| Activation of a synapse weakening pathway by human Val66 but not Met66 pro-brain-derived neurotrophic factor (proBDNF) S Kailainathan, TM Piers, JH Yi, S Choi, MS Fahey, E Borger, ... Pharmacological Research 104, 97-107, 2016 | 30 | 2016 |
| Abrogation of LRRK2 dependent Rab10 phosphorylation with TLR4 activation and alterations in evoked cytokine release in immune cells I Nazish, C Arber, TM Piers, TT Warner, JA Hardy, PA Lewis, JM Pocock, ... Neurochemistry international 147, 105070, 2021 | 19 | 2021 |
| Soluble fibrinogen triggers non-cell autonomous ER stress-mediated microglial-induced neurotoxicity TM Piers, E East, C Villegas-Llerena, IG Sevastou, M Matarin, J Hardy, ... Frontiers in Cellular Neuroscience 12, 404, 2018 | 19 | 2018 |
