| Functional significance of the perforin/granzyme cell death pathway JA Trapani, MJ Smyth Nature Reviews Immunology 2 (10), 735-747, 2002 | 1714 | 2002 |
| Perforin and granzymes: function, dysfunction and human pathology I Voskoboinik, JC Whisstock, JA Trapani Nature Reviews Immunology 15 (6), 388-400, 2015 | 1315 | 2015 |
| Differential tumor surveillance by natural killer (NK) and NKT cells MJ Smyth, KYT Thia, SEA Street, E Cretney, JA Trapani, M Taniguchi, ... The Journal of experimental medicine 191 (4), 661-668, 2000 | 1128 | 2000 |
| A fresh look at tumor immunosurveillance and immunotherapy MJ Smyth, DI Godfrey, JA Trapani Nature immunology 2 (4), 293-299, 2001 | 1080 | 2001 |
| In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. T Fernandes-Alnemri, RC Armstrong, J Krebs, SM Srinivasula, L Wang, ... Proceedings of the National Academy of Sciences 93 (15), 7464-7469, 1996 | 1024 | 1996 |
| Perforin-mediated cytotoxicity is critical for surveillance of spontaneous lymphoma MJ Smyth, KYT Thia, SEA Street, D MacGregor, DI Godfrey, JA Trapani The Journal of experimental medicine 192 (5), 755-760, 2000 | 831 | 2000 |
| Type I IFNs enhance the terminal differentiation of dendritic cells T Luft, KC Pang, E Thomas, P Hertzog, DNJ Hart, J Trapani, J Cebon The Journal of Immunology 161 (4), 1947-1953, 1998 | 811 | 1998 |
| CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity ML Burr, CE Sparbier, YC Chan, JC Williamson, K Woods, PA Beavis, ... Nature 549 (7670), 101-105, 2017 | 785 | 2017 |
| Perforin-mediated target-cell death and immune homeostasis I Voskoboinik, MJ Smyth, JA Trapani Nature Reviews Immunology 6 (12), 940-952, 2006 | 737 | 2006 |
| Granzymes: exogenous porteinases that induce target cell apoptosis MJ Smyth, JA Trapani Immunology today 16 (4), 202-206, 1995 | 537 | 1995 |
| Suppression of lymphoma and epithelial malignancies effected by interferon γ SEA Street, JA Trapani, D MacGregor, MJ Smyth The Journal of experimental medicine 196 (1), 129-134, 2002 | 534 | 2002 |
| Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B–mediated caspase activation VR Sutton, JE Davis, M Cancilla, RW Johnstone, AA Ruefli, K Sedelies, ... The Journal of experimental medicine 192 (10), 1403-1414, 2000 | 523 | 2000 |
| Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia DS Ritchie, PJ Neeson, A Khot, S Peinert, T Tai, K Tainton, K Chen, ... Molecular Therapy 21 (11), 2122-2129, 2013 | 510 | 2013 |
| The structural basis for membrane binding and pore formation by lymphocyte perforin RHP Law, N Lukoyanova, I Voskoboinik, TT Caradoc-Davies, K Baran, ... Nature 468 (7322), 447-451, 2010 | 490 | 2010 |
| The Ced-3/interleukin 1β converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2α are substrates for the apoptotic mediator CPP32 SM Srinivasula, T Fernandes-Alnemri, J Zangrilli, N Robertson, ... Journal of Biological Chemistry 271 (43), 27099-27106, 1996 | 428 | 1996 |
| Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation SS Metkar, B Wang, M Aguilar-Santelises, SM Raja, L Uhlin-Hansen, ... Immunity 16 (3), 417-428, 2002 | 400 | 2002 |
| Selective regulation of apoptosis: the cytotoxic lymphocyte serpin proteinase inhibitor 9 protects against granzyme B-mediated apoptosis without perturbing the Fas cell death … CH Bird, VR Sutton, J Sun, CE Hirst, A Novak, S Kumar, JA Trapani, ... Molecular and cellular biology 18 (11), 6387-6398, 1998 | 385 | 1998 |
| Discordant regulation of granzyme H and granzyme B expression in human lymphocytes KA Sedelies, TJ Sayers, KM Edwards, W Chen, DG Pellicci, DI Godfrey, ... Journal of biological chemistry 279 (25), 26581-26587, 2004 | 374 | 2004 |
| A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes J Sun, CH Bird, V Sutton, L McDonald, PB Coughlin, TA De Jong, ... Journal of Biological Chemistry 271 (44), 27802-27809, 1996 | 370 | 1996 |
| Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin MS Buzza, L Zamurs, J Sun, CH Bird, AI Smith, JA Trapani, CJ Froelich, ... Journal of Biological Chemistry 280 (25), 23549-23558, 2005 | 349 | 2005 |
