| De novo design of potent and selective mimics of IL-2 and IL-15 DA Silva, S Yu, UY Ulge, JB Spangler, KM Jude, C Labão-Almeida, LR Ali, ... Nature 565 (7738), 186-191, 2019 | 411 | 2019 |
| Insights into cytokine–receptor interactions from cytokine engineering JB Spangler, I Moraga, JL Mendoza, KC Garcia Annual review of immunology 33, 139-167, 2015 | 257 | 2015 |
| Antibodies to interleukin-2 elicit selective T cell subset potentiation through distinct conformational mechanisms JB Spangler, J Tomala, VC Luca, KM Jude, S Dong, AM Ring, P Votavova, ... Immunity 42 (5), 815-825, 2015 | 233 | 2015 |
| Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling JB Spangler, JR Neil, S Abramovitch, Y Yarden, FM White, ... Proceedings of the National Academy of Sciences 107 (30), 13252-13257, 2010 | 177 | 2010 |
| Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps S Mitra, AM Ring, S Amarnath, JB Spangler, P Li, W Ju, S Fischer, J Oh, ... Immunity 42 (5), 826-838, 2015 | 165 | 2015 |
| Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells CR Glassman, YK Mathiharan, KM Jude, L Su, O Panova, PJ Lupardus, ... Cell 184 (4), 983-999. e24, 2021 | 87 | 2021 |
| Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers I Moraga, JB Spangler, JL Mendoza, M Gakovic, TS Wehrman, P Krutzik, ... Elife 6, e22882, 2017 | 72 | 2017 |
| Multifarious determinants of cytokine receptor signaling specificity I Moraga, J Spangler, JL Mendoza, KC Garcia Advances in immunology 121, 1-39, 2014 | 71 | 2014 |
| Engineering a single-agent cytokine/antibody fusion that selectively expands regulatory T cells for autoimmune disease therapy JB Spangler, E Trotta, J Tomala, A Peck, TA Young, CS Savvides, ... The Journal of Immunology 201 (7), 2094-2106, 2018 | 64 | 2018 |
| Engineered proteins including mutant fibronectin domains KD Wittrup, JB Spangler, BJ Hackel US Patent App. 13/390,086, 2012 | 58 | 2012 |
| Triepitopic antibody fusions inhibit cetuximab-resistant BRAF and KRAS mutant tumors via EGFR signal repression JB Spangler, MT Manzari, EK Rosalia, TF Chen, KD Wittrup Journal of molecular biology 422 (4), 532-544, 2012 | 50 | 2012 |
| IgM autoantibodies recognizing ACE2 are associated with severe COVID-19 L Casciola-Rosen, DR Thiemann, F Andrade, MIT Zambrano, JE Hooper, ... MedRxiv, 2020 | 45 | 2020 |
| Effect of pathogenic cysteine mutations on FGFR3 transmembrane domain dimerization in detergents and lipid bilayers M You, J Spangler, E Li, X Han, P Ghosh, K Hristova Biochemistry 46 (39), 11039-11046, 2007 | 40 | 2007 |
| Synthesis and initial characterization of FGFR3 transmembrane domain: consequences of sequence modifications T Iwamoto, M You, E Li, J Spangler, JM Tomich, K Hristova Biochimica et Biophysica Acta (BBA)-Biomembranes 1668 (2), 240-247, 2005 | 39 | 2005 |
| Engineering cytokine therapeutics J Deckers, T Anbergen, AM Hokke, A de Dreu, DP Schrijver, K de Bruin, ... Nature Reviews Bioengineering 1 (4), 286-303, 2023 | 37 | 2023 |
| Suspendable hydrogel nanovials for massively parallel single-cell functional analysis and sorting J De Rutte, R Dimatteo, MM Archang, M Van Zee, D Koo, S Lee, ... ACS nano 16 (5), 7242-7257, 2022 | 36 | 2022 |
| A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy A Quijano-Rubio, AM Bhuiyan, H Yang, I Leung, E Bello, LR Ali, ... Nature biotechnology 41 (4), 532-540, 2023 | 31 | 2023 |
| IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function L Casciola-Rosen, DR Thiemann, F Andrade, MI Trejo-Zambrano, ... JCI insight 7 (9), 2022 | 28 | 2022 |
| Strategies for glycoengineering therapeutic proteins K Dammen-Brower, P Epler, S Zhu, ZJ Bernstein, PR Stabach, ... Frontiers in Chemistry 10, 863118, 2022 | 26 | 2022 |
| Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection D VanDyke, M Iglesias, J Tomala, A Young, J Smith, JA Perry, E Gebara, ... Cell reports 41 (3), 2022 | 25 | 2022 |
