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Paul GeurinkAssistant professor, LUMCDirección de correo verificada de lumc.nl
Jacques NeefjesHoogleraar cell biologie en immunologie, Leiden UniversiteitDirección de correo verificada de nki.nl
Hidde PloeghSenior Investigator, Program in Cellular and Molecular Medicine, Boston Children's HospitalDirección de correo verificada de childrens.harvard.edu
Ton N.M. SchumacherThe Netherlands Cancer Institute, Third Rock VenturesDirección de correo verificada de nki.nl
H.S. OverkleeftProfessor of Bio-organic Synthesis, Leiden UniversityDirección de correo verificada de lic.leidenuniv.nl
Benedikt KesslerProfessor of Biochemistry and Life Science Mass Spectrometry, University of Oxford, UKDirección de correo verificada de ndm.ox.ac.uk
Reggy EkkebusNetherlands Cancer InstituteDirección de correo verificada de nki.nl
David KomanderUbiquitin Signalling Division, Walter and Eliza Hall Institute of Medical Research, MelbourneDirección de correo verificada de wehi.edu.au
Dharjath S HameedPost-Doc, LUMC LeidenDirección de correo verificada de lumc.nl
Alfred VertegaalLeiden University Medical CenterDirección de correo verificada de lumc.nl
Titia K. SixmaDivision of Biochemistry, Netherlands Cancer Institute, AmsterdamDirección de correo verificada de nki.nl
Ilana BerlinLUMCDirección de correo verificada de lumc.nl
Albert J. R. HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center and Utrecht UniversityDirección de correo verificada de uu.nl
Anastassis PerrakisDivision of Biochemistry, Netherlands Cancer Institute and Oncode Institute, Prof Utrecht UDirección de correo verificada de nki.nl
Yogesh KulathuMRC Protein Phosphorylation & Ubiquitylation Unit, University of DundeeDirección de correo verificada de dundee.ac.uk
Lennert JanssenDirección de correo verificada de lumc.nl
Tycho E.T. Mevissen, PhDHarvard Medical SchoolDirección de correo verificada de hms.harvard.edu
Laurens A van MeeterenUtrecht UniversityDirección de correo verificada de uu.nl
Patrick CelieProtein Facility Manager at The Netherlands cancer Institute (NKI)Dirección de correo verificada de nki.nl
Dmitri V. FilippovLeiden UniversityDirección de correo verificada de chem.leidenuniv.nl

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huib ovaa

lumc and leiden university

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drug design ub(l) signal transduction proteasome function


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity D Shin, R Mukherjee, D Grewe, D Bojkova, K Baek, A Bhattacharya, ... Nature 587 (7835), 657-662, 2020	1010	2020
Generation of peptide–MHC class I complexes through UV-mediated ligand exchange B Rodenko, M Toebes, SR Hadrup, WJE Van Esch, AM Molenaar, ... Nature protocols 1 (3), 1120-1132, 2006	943	2006
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib D Chauhan, L Catley, G Li, K Podar, T Hideshima, M Velankar, ... Cancer cell 8 (5), 407-419, 2005	846	2005
Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family A Borodovsky, H Ovaa, N Kolli, T Gan-Erdene, KD Wilkinson, HL Ploegh, ... Chemistry & biology 9 (10), 1149-1159, 2002	669	2002
OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis TET Mevissen, MK Hospenthal, PP Geurink, PR Elliott, M Akutsu, ... Cell 154 (1), 169-184, 2013	610	2013
Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome M Groll, CR Berkers, HL Ploegh, H Ovaa Structure 14 (3), 451-456, 2006	598	2006
Proteome-wide identification of ubiquitin interactions using UbIA-MS X Zhang, AH Smits, GBA Van Tilburg, H Ovaa, W Huber, M Vermeulen Nature protocols 13 (3), 530-550, 2018	572	2018
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin B Pang, X Qiao, L Janssen, A Velds, T Groothuis, R Kerkhoven, ... Nature communications 4 (1), 1908, 2013	456	2013
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2 T Klemm, G Ebert, DJ Calleja, CC Allison, LW Richardson, JP Bernardini, ... The EMBO journal 39 (18), e106275, 2020	430	2020
Design and use of conditional MHC class I ligands M Toebes, M Coccoris, A Bins, B Rodenko, R Gomez, NJ Nieuwkoop, ... Nature medicine 12 (2), 246-251, 2006	418	2006
On terminal alkynes that can react with active-site cysteine nucleophiles in proteases R Ekkebus, SI van Kasteren, Y Kulathu, A Scholten, I Berlin, PP Geurink, ... Journal of the American Chemical Society 135 (8), 2867-2870, 2013	360	2013
Chemical synthesis of ubiquitin, ubiquitin‐based probes, and diubiquitin F El Oualid, R Merkx, R Ekkebus, DS Hameed, JJ Smit, A de Jong, ... Angewandte Chemie 122 (52), 10347-10351, 2010	339	2010
Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity J van Loosdregt, V Fleskens, J Fu, AB Brenkman, CPJ Bekker, ... Immunity 39 (2), 259-271, 2013	337	2013
Structural basis of substrate discrimination and integrin binding by autotaxin J Hausmann, S Kamtekar, E Christodoulou, JE Day, T Wu, Z Fulkerson, ... Nature structural & molecular biology 18 (2), 198-204, 2011	336	2011
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 E Meulmeester, MM Maurice, C Boutell, AFAS Teunisse, H Ovaa, ... Molecular cell 18 (5), 565-576, 2005	335	2005
CEP-18770: A novel, orally active proteasome inhibitor with a tumor-selective pharmacologic profile competitive with bortezomib R Piva, B Ruggeri, M Williams, G Costa, I Tamagno, D Ferrero, V Giai, ... Blood, The Journal of the American Society of Hematology 111 (5), 2765-2775, 2008	330	2008
Disease-associated prion protein oligomers inhibit the 26S proteasome M Kristiansen, P Deriziotis, DE Dimcheff, GS Jackson, H Ovaa, ... Molecular cell 26 (2), 175-188, 2007	330	2007
Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib CR Berkers, M Verdoes, E Lichtman, E Fiebiger, BM Kessler, ... Nature methods 2 (5), 357-362, 2005	323	2005
Differential dependence of CD4+ CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation M Schmidt-Supprian, J Tian, EP Grant, M Pasparakis, R Maehr, H Ovaa, ... Proceedings of the National Academy of Sciences 101 (13), 4566-4571, 2004	288	2004
Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity PC Evans, H Ovaa, M Hamon, PJ Kilshaw, S Hamm, S Bauer, HL Ploegh, ... Biochemical Journal 378 (3), 727-734, 2004	286	2004

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