Gene expression profiling predicts clinical outcome of breast cancer LJ Van't Veer, H Dai, MJ Van De Vijver, YD He, AAM Hart, M Mao, ... nature 415 (6871), 530-536, 2002 | 11956 | 2002 |
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs LP Lim, NC Lau, P Garrett-Engele, A Grimson, JM Schelter, J Castle, ... Nature 433 (7027), 769-773, 2005 | 6058 | 2005 |
A microRNA component of the p53 tumour suppressor network L He, X He, LP Lim, E De Stanchina, Z Xuan, Y Liang, W Xue, L Zender, ... Nature 447 (7148), 1130-1134, 2007 | 3396 | 2007 |
Expression profiling reveals off-target gene regulation by RNAi AL Jackson, SR Bartz, J Schelter, SV Kobayashi, J Burchard, M Mao, B Li, ... Nature biotechnology 21 (6), 635-637, 2003 | 3176 | 2003 |
CTLA-4 can function as a negative regulator of T cell activation TL Walunas, DJ Lenschow, CY Bakker, PS Linsley, GJ Freeman, ... Immunity 1 (5), 405-413, 1994 | 2836 | 1994 |
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data G Finak, A McDavid, M Yajima, J Deng, V Gersuk, AK Shalek, CK Slichter, ... Genome biology 16, 1-13, 2015 | 2650 | 2015 |
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms RV Parry, JM Chemnitz, KA Frauwirth, AR Lanfranco, I Braunstein, ... Molecular and cellular biology 25 (21), 9543-9553, 2005 | 2376 | 2005 |
CTLA-4 is a second receptor for the B cell activation antigen B7. PS Linsley, W Brady, M Urnes, LS Grosmaire, NK Damle, JA Ledbetter The Journal of experimental medicine 174 (3), 561-569, 1991 | 2274 | 1991 |
Genetics of gene expression surveyed in maize, mouse and man EE Schadt, SA Monks, TA Drake, AJ Lusis, N Che, V Colinayo, TG Ruff, ... Nature 422 (6929), 297-302, 2003 | 1916 | 2003 |
The role of the CD28 receptor during T cell responses to antigen. PS Linsley, JA Ledbetter Annual review of immunology 11, 191-212, 1993 | 1801 | 1993 |
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways CP Larsen, ET Elwood, DZ Alexander, SC Ritchie, R Hendrix, ... Nature 381 (6581), 434-438, 1996 | 1769 | 1996 |
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer TR Hughes, M Mao, AR Jones, J Burchard, MJ Marton, KW Shannon, ... Nature biotechnology 19 (4), 342-347, 2001 | 1663 | 2001 |
Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. PS Linsley, W Brady, L Grosmaire, A Aruffo, NK Damle, JA Ledbetter The Journal of experimental medicine 173 (3), 721-730, 1991 | 1650 | 1991 |
Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4lg DJ Lenschow, Y Zeng, JR Thistlethwaite, A Montag, W Brady, MG Gibson, ... Science 257 (5071), 789-792, 1992 | 1488 | 1992 |
A large-scale RNAi screen in human cells identifies new components of the p53 pathway K Berns, EM Hijmans, J Mullenders, TR Brummelkamp, A Velds, ... Nature 428 (6981), 431-437, 2004 | 1475 | 2004 |
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4 L Chen, S Ashe, WA Brady, I Hellström, KE Hellström, JA Ledbetter, ... Cell 71 (7), 1093-1102, 1992 | 1451 | 1992 |
Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors PS Linsley, JAL Greene, W Brady, J Bajorath, JA Ledbetter, R Peach Immunity 1 (9), 793-801, 1994 | 1347 | 1994 |
Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application AL Jackson, PS Linsley Nature reviews Drug discovery 9 (1), 57-67, 2010 | 1330 | 2010 |
Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity AL Jackson, J Burchard, J Schelter, BN Chau, M Cleary, L Lim, PS Linsley Rna 12 (7), 1179-1187, 2006 | 1295 | 2006 |
MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators G Gabriely, T Wurdinger, S Kesari, CC Esau, J Burchard, PS Linsley, ... Molecular and cellular biology 28 (17), 5369-5380, 2008 | 1150 | 2008 |