Understanding the tumor immune microenvironment (TIME) for effective therapy M Binnewies, EW Roberts, K Kersten, V Chan, DF Fearon, M Merad, ... Nature medicine 24 (5), 541-550, 2018 | 4564 | 2018 |
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis SB Coffelt, K Kersten, CW Doornebal, J Weiden, K Vrijland, CS Hau, ... Nature 522 (7556), 345-348, 2015 | 1729 | 2015 |
Unleashing type-2 dendritic cells to drive protective antitumor CD4+ T cell immunity M Binnewies, AM Mujal, JL Pollack, AJ Combes, EA Hardison, KC Barry, ... Cell 177 (3), 556-571. e16, 2019 | 564 | 2019 |
Genetically engineered mouse models in oncology research and cancer medicine K Kersten, KE de Visser, MH van Miltenburg, J Jonkers EMBO molecular medicine 9 (2), 137-153, 2017 | 512 | 2017 |
Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer K Kersten, KH Hu, AJ Combes, B Samad, T Harwin, A Ray, AA Rao, E Cai, ... Cancer Cell 40 (6), 624-638. e9, 2022 | 185 | 2022 |
An expanded universe of cancer targets WC Hahn, JS Bader, TP Braun, A Califano, PA Clemons, BJ Druker, ... Cell 184 (5), 1142-1155, 2021 | 170 | 2021 |
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response C Salvagno, M Ciampricotti, S Tuit, CS Hau, A van Weverwijk, SB Coffelt, ... Nature cell biology 21 (4), 511-521, 2019 | 167 | 2019 |
ZipSeq: barcoding for real-time mapping of single cell transcriptomes KH Hu, JP Eichorst, CS McGinnis, DM Patterson, ED Chow, K Kersten, ... Nature methods 17 (8), 833-843, 2020 | 128 | 2020 |
Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival M Sobral-Leite, K Van de Vijver, M Michaut, R van der Linden, ... Oncoimmunology 7 (12), e1509820, 2018 | 121 | 2018 |
Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages K Kersten, SB Coffelt, M Hoogstraat, NJM Verstegen, K Vrijland, ... Oncoimmunology 6 (8), e1334744, 2017 | 121 | 2017 |
IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer OS Blomberg, L Spagnuolo, H Garner, L Voorwerk, OI Isaeva, E van Dyk, ... Cancer Cell 41 (1), 106-123. e10, 2023 | 116 | 2023 |
Adaptive immune regulation of mammary postnatal organogenesis V Plaks, B Boldajipour, JR Linnemann, NH Nguyen, K Kersten, Y Wolf, ... Developmental cell 34 (5), 493-504, 2015 | 110 | 2015 |
Exploiting the immunomodulatory properties of chemotherapeutic drugs to improve the success of cancer immunotherapy K Kersten, C Salvagno, KE De Visser Frontiers in immunology 6, 516, 2015 | 92 | 2015 |
MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling D Zimmerli, CS Brambillasca, F Talens, J Bhin, R Linstra, L Romanens, ... Nature communications 13 (1), 6579, 2022 | 59 | 2022 |
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment KM Tharp, K Kersten, O Maller, GA Timblin, C Stashko, FP Canale, ... Nature Cancer, 1-18, 2024 | 19 | 2024 |
Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system S Klarenbeek, CW Doornebal, SM Kas, N Bonzanni, J Bhin, ... Oncoimmunology 9 (1), 1724049, 2020 | 13 | 2020 |
Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast … OS Blomberg, K Kos, L Spagnuolo, OI Isaeva, H Garner, MD Wellenstein, ... Oncoimmunology 12 (1), 2201147, 2023 | 11 | 2023 |
Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung K Kersten, R You, S Liang, KM Tharp, J Pollack, VM Weaver, MF Krummel, ... Cell reports 42 (6), 2023 | 7 | 2023 |
MYC promotes immune-suppression in TNBC via inhibition of IFN signaling D Zimmerli, CS Brambillasca, F Talens, J Bhin, A Bhattacharya, ... bioRxiv, 2021.02. 24.432659, 2021 | 7 | 2021 |
LBA10 Critical role of eosinophils during response to immune checkpoint blockade in breast cancer and other cancer types L Voorwerk, H Garner, OS Blomberg, L Spagnuolo, M Chalabi, E van Dyk, ... Annals of Oncology 31, S1142, 2020 | 6 | 2020 |