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Improving neutralization potency and breadth by combining broadly reactive HIV-1 antibodies targeting major neutralization epitopes R Kong, MK Louder, K Wagh, RT Bailer, A deCamp, K Greene, H Gao, ... Journal of virology 89 (5), 2659-2671, 2015 | 138 | 2015 |
Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy C Gruber, M Martin-Fernandez, F Ailal, X Qiu, J Taft, J Altman, J Rosain, ... Journal of Experimental Medicine 217 (5), 2020 | 90 | 2020 |
Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death J Taft, M Markson, D Legarda, R Patel, M Chan, L Malle, A Richardson, ... Cell 184 (17), 4447-4463. e20, 2021 | 79 | 2021 |
A neutralizing antibody recognizing primarily N-linked glycan targets the silent face of the HIV envelope T Zhou, A Zheng, U Baxa, GY Chuang, IS Georgiev, R Kong, S O’Dell, ... Immunity 48 (3), 500-513. e6, 2018 | 79 | 2018 |
An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants S Tanaka, G Nelson, CA Olson, O Buzko, W Higashide, A Shin, ... Scientific Reports 11 (1), 12740, 2021 | 58 | 2021 |
Sendai virus, an RNA virus with no risk of genomic integration, delivers CRISPR/Cas9 for efficient gene editing A Park, P Hong, ST Won, PA Thibault, F Vigant, KY Oguntuyo, JD Taft, ... Molecular therapy Methods & clinical development 3, 2016 | 52 | 2016 |
A partial form of inherited human USP18 deficiency underlies infection and inflammation M Martin-Fernandez, S Buta, T Le Voyer, Z Li, LT Dynesen, F Vuillier, ... Journal of Experimental Medicine 219 (4), e20211273, 2022 | 36 | 2022 |
The Goldilocks zone of type I IFNs: lessons from human genetics J Taft, D Bogunovic The Journal of Immunology 201 (12), 3479-3485, 2018 | 33 | 2018 |
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells L Malle, RS Patel, M Martin-Fernandez, OJ Stewart, Q Philippot, S Buta, ... Nature 615 (7951), 305-314, 2023 | 29 | 2023 |
ISG15 deficiency restricts HIV-1 infection D Jurczyszak, L Manganaro, S Buta, C Gruber, M Martin-Fernandez, J Taft, ... PLoS Pathogens 18 (3), e1010405, 2022 | 16 | 2022 |
Dioxin Exposure Alters Molecular and Morphological Responses to Thyroid Hormone in Xenopus laevis Cultured Cells and Prometamorphic Tadpoles JD Taft, MM Colonnetta, RE Schafer, N Plick, WH Powell Toxicological Sciences 161 (1), 196-206, 2018 | 16 | 2018 |
Rapid identification of neutralizing antibodies against SARS-CoV-2 variants by mRNA display S Tanaka, CA Olson, CO Barnes, W Higashide, M Gonzalez, J Taft, ... Cell Reports 38 (6), 2022 | 14 | 2022 |
Prime hAd5 spike+ nucleocapsid vaccination induces ten-fold increases in mean T-cell responses in phase 1 subjects that are sustained against spike variants P Sieling, T King, R Wong, A Nguyen, K Wnuk, E Gabitzsch, A Rice, ... medRxiv, 2021.04. 05.21254940, 2021 | 14 | 2021 |
Type I IFN is siloed in endosomes JB Altman, J Taft, T Wedeking, CN Gruber, M Holtmannspötter, J Piehler, ... Proceedings of the National Academy of Sciences 117 (30), 17510-17512, 2020 | 14 | 2020 |
Developing Broad-Spectrum Antivirals Using Porcine and Rhesus Macaque Models X Qiu, J Taft, D Bogunovic The Journal of Infectious Diseases 221 (6), 890-894, 2020 | 5 | 2020 |
Structural basis of glycan276-dependent recognition by HIV-1 broadly neutralizing antibodies CA Cottrell, K Manne, R Kong, S Wang, T Zhou, GY Chuang, RJ Edwards, ... Cell reports 37 (5), 2021 | 4 | 2021 |
Antibodies targeting the fusion peptide on the HIV envelope provide protection to rhesus macaques against mucosal SHIV challenge A Pegu, SE Lovelace, ME DeMouth, MD Cully, DJ Morris, Y Li, K Wang, ... Science Translational Medicine 16 (730), eadh9039, 2024 | 2 | 2024 |
Plasticity of the Type-I Interferon System Demonstrated by a Developing Antiviral and a Novel Inborn Error of Immunity J Taft Icahn School of Medicine at Mount Sinai, 2021 | | 2021 |