Targeting cytochrome P450 (CYP) 1B1 enzyme with four series of A-ring substituted estrane derivatives: design, synthesis, inhibitory activity, and selectivity R Dutour, J Roy, F Cortés-Benítez, R Maltais, D Poirier Journal of Medicinal Chemistry 61 (20), 9229-9245, 2018 | 31 | 2018 |
Cytotoxic effect of novel dehydroepiandrosterone derivatives on different cancer cell lines M Garrido, M Cabeza, F Cortés, J Gutiérrez, E Bratoeff European Journal of Medicinal Chemistry 68, 301-311, 2013 | 21 | 2013 |
Structure-based design and synthesis of new estrane–pyridine derivatives as cytochrome P450 (CYP) 1B1 Inhibitors R Dutour, F Cortés-Benítez, J Roy, D Poirier ACS Medicinal Chemistry Letters 8 (11), 1159-1164, 2017 | 18 | 2017 |
Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line F Cortés-Benítez, M Cabeza, MT Ramírez-Apan, B Alvarez-Manrique, ... European Journal of Medicinal Chemistry 121, 737-746, 2016 | 17 | 2016 |
Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives K Rodríguez-Villar, L Yépez-Mulia, M Cortés-Gines, JD Aguilera-Perdomo, ... Molecules 26 (8), 2145, 2021 | 13 | 2021 |
Indole-and pyrazole-glycyrrhetinic acid derivatives as PTP1B inhibitors: Synthesis, in vitro and in silico studies L De-la-Cruz-Martínez, C Duran-Becerra, M González-Andrade, ... Molecules 26 (14), 4375, 2021 | 12 | 2021 |
Impact of androstane A-and D-ring inversion on 17β-hydroxysteroid dehydrogenase type 3 inhibitory activity, androgenic effect and metabolic stability F Cortes-Benitez, J Roy, R Maltais, D Poirier Bioorganic & Medicinal Chemistry 25 (7), 2065-2073, 2017 | 11 | 2017 |
Design, synthesis and anticandidal evaluation of indazole and pyrazole derivatives K Rodríguez-Villar, A Hernández-Campos, L Yépez-Mulia, ... Pharmaceuticals 14 (3), 176, 2021 | 9 | 2021 |
A-and D-ring structural modifications of an androsterone derivative inhibiting 17β-hydroxysteroid dehydrogenase type 3: Chemical synthesis and structure–activity relationships F Cortés-Benítez, J Roy, M Perreault, R Maltais, D Poirier Journal of Medicinal Chemistry 62 (15), 7070-7088, 2019 | 9 | 2019 |
Targeting cytochrome P450 (CYP) 1B1 with steroid derivatives D Poirier, J Roy, F Cortés-Benítez, R Dutour Bioorganic & Medicinal Chemistry Letters 26 (21), 5272-5276, 2016 | 9 | 2016 |
Biological evaluation of androstene derivatives M Garrido, E Bratoeff, M García‐Lorenzana, Y Heuze, J Soriano, ... Archiv der Pharmazie 346 (1), 62-70, 2013 | 9 | 2013 |
16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology … F Cortés-Benítez, J Roy, M Perreault, R Maltais, D Poirier The Journal of Steroid Biochemistry and Molecular Biology 210, 105846, 2021 | 8 | 2021 |
Activity landscape analysis of novel 5-reductase inhibitors JJ Naveja, F Cortés-Benítez, E Bratoeff, JL Medina-Franco Molecular diversity 20 (3), 771-780, 2016 | 8 | 2016 |
Biological activity of pyrazole and imidazole-dehydroepiandrosterone derivatives on the activity of 17β-hydroxysteroid dehydrogenase M Cabeza, A Posada, A Sánchez-Márquez, Y Heuze, I Moreno, J Soriano, ... Journal of enzyme inhibition and medicinal chemistry 31 (1), 53-62, 2016 | 8 | 2016 |
Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2H-indazole Hybrids J Pérez-Villanueva, F Matadamas-Martínez, L Yépez-Mulia, ... Pharmaceuticals 14 (8), 815, 2021 | 6 | 2021 |
The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: a ligand-based virtual screening and in vitro study J Perez-Villanueva, L Yepez-Mulia, K Rodriguez-Villar, F Cortes-Benitez, ... European Journal of Medicinal Chemistry 211, 113110, 2021 | 5 | 2021 |
The importance of including the C-terminal domain of PTP1B1-400 to identify potential antidiabetic inhibitors A Coronell-Tovar, F Cortés-Benítez, M González-Andrade Journal of Enzyme Inhibition and Medicinal Chemistry 38 (1), 2170369, 2023 | 1 | 2023 |
Anti-Diabetic Activity of Glycyrrhetinic Acid Derivatives FC-114 and FC-122: Scale-Up, In Silico, In Vitro, and In Vivo Studies S Álvarez-Almazán, LC Solís-Domínguez, P Duperou-Luna, ... International Journal of Molecular Sciences 24 (16), 12812, 2023 | 1 | 2023 |
Chemical synthesis of fluorinated and iodinated 17β-HSD3 inhibitors and evaluation for imaging prostate cancer tumors and tissue biodistribution D Poirier, R Maltais, JA Rousseau, J Roy, S Phoenix, F Cortés-Benítez, ... Bioorganic Chemistry 129, 106145, 2022 | 1 | 2022 |
Synthesis and Antitumor Activity of 2,3‐Diphenyl‐2H‐indazole Derivatives as Potent Antitubulin Agents F Matadamas‐Martínez, L Yépez‐Mulia, V Pérez‐Koldenkova, ... ChemistrySelect 7 (27), e202202056, 2022 | 1 | 2022 |