| Persistent epigenetic differences associated with prenatal exposure to famine in humans BT Heijmans, EW Tobi, AD Stein, H Putter, GJ Blauw, ES Susser, ... Proceedings of the National Academy of Sciences 105 (44), 17046-17049, 2008 | 3659 | 2008 |
| Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression U Vősa, A Claringbould, HJ Westra, MJ Bonder, P Deelen, B Zeng, ... Nature genetics 53 (9), 1300-1310, 2021 | 1393* | 2021 |
| DNA methylation differences after exposure to prenatal famine are common and timing-and sex-specific EW Tobi, LH Lumey, RP Talens, D Kremer, H Putter, AD Stein, ... Human molecular genetics 18 (21), 4046-4053, 2009 | 1343 | 2009 |
| Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity S Wahl, A Drong, B Lehne, M Loh, WR Scott, S Kunze, PC Tsai, JS Ried, ... Nature 541 (7635), 81-86, 2017 | 898 | 2017 |
| DNA methylation aging clocks: challenges and recommendations CG Bell, R Lowe, PD Adams, AA Baccarelli, S Beck, JT Bell, ... Genome biology 20, 1-24, 2019 | 753 | 2019 |
| DNA methylation signatures link prenatal famine exposure to growth and metabolism EW Tobi, JJ Goeman, R Monajemi, H Gu, H Putter, Y Zhang, RC Slieker, ... Nature communications 5 (1), 5592, 2014 | 624 | 2014 |
| Periconceptional maternal folic acid use of 400 µg per day is related to increased methylation of the IGF2 gene in the very young child RP Steegers-Theunissen, SA Obermann-Borst, D Kremer, J Lindemans, ... PloS one 4 (11), e7845, 2009 | 559 | 2009 |
| Disease variants alter transcription factor levels and methylation of their binding sites MJ Bonder, R Luijk, D Zhernakova, M Moed, P Deelen, M Vermaat, ... Nature genetics 49 (1), 131–138, 2017 | 469 | 2017 |
| Identification of context-dependent expression quantitative trait loci in whole blood DV Zhernakova, P Deelen, M Vermaat, M Van Iterson, M Van Galen, ... Nature genetics 49 (1), 139-145, 2017 | 465 | 2017 |
| From promises to practical strategies in epigenetic epidemiology J Mill, BT Heijmans Nature Reviews Genetics 14 (8), 585-594, 2013 | 394 | 2013 |
| Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs RP Talens, K Christensen, H Putter, G Willemsen, L Christiansen, ... Aging cell 11 (4), 694-703, 2012 | 391 | 2012 |
| Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology RP Talens, DI Boomsma, EW Tobi, D Kremer, JW Jukema, G Willemsen, ... The FASEB Journal 24 (9), 3135-3144, 2010 | 370 | 2010 |
| Genetic and environmental influences interact with age and sex in shaping the human methylome J Van Dongen, MG Nivard, G Willemsen, JJ Hottenga, Q Helmer, ... Nature communications 7 (1), 11115, 2016 | 368 | 2016 |
| Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation N Kato, M Loh, F Takeuchi, N Verweij, X Wang, W Zhang, TN Kelly, ... Nature genetics 47 (11), 1282-1293, 2015 | 366 | 2015 |
| Reduced insulin/IGF‐1 signalling and human longevity D Van Heemst, M Beekman, SP Mooijaart, BT Heijmans, BW Brandt, ... Aging cell 4 (2), 79-85, 2005 | 363 | 2005 |
| Genome‐wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas, L Christiansen, ... Aging cell 10 (4), 686-698, 2011 | 323 | 2011 |
| Controlling bias and inflation in epigenome-and transcriptome-wide association studies using the empirical null distribution M van Iterson, EW van Zwet, Bios Consortium, BT Heijmans Genome biology 18, 1-13, 2017 | 314 | 2017 |
| Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study RGJ Westendorp, D Van Heemst, MP Rozing, M Frölich, SP Mooijaart, ... Journal of the American Geriatrics Society 57 (9), 1634-1637, 2009 | 310 | 2009 |
| The epigenome: archive of the prenatal environment BT Heijmans, EW Tobi, LH Lumey, PE Slagboom Epigenetics 4 (8), 526-531, 2009 | 309 | 2009 |
| Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus BT Heijmans, D Kremer, EW Tobi, DI Boomsma, PE Slagboom Human molecular genetics 16 (5), 547-554, 2007 | 300 | 2007 |
