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Mark J O'Connor
Mark J O'Connor
AstraZeneca Oncology UK
Dirección de correo verificada de astrazeneca.com
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Inhibition of Poly(ADP-Ribose) Polymerase in Tumors from BRCA Mutation Carriers
PC Fong, DS Boss, TA Yap, A Tutt, P Wu, M Mergui-Roelvink, P Mortimer, ...
New England Journal of Medicine 361 (2), 123-134, 2009
44292009
Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly (ADP-ribose) polymerase inhibition
N McCabe, NC Turner, CJ Lord, K Kluzek, A Białkowska, S Swift, ...
Cancer research 66 (16), 8109-8115, 2006
15172006
Targeting the DNA damage response in cancer
MJ O’Connor
Molecular cell 60 (4), 547-560, 2015
15152015
High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs
S Rottenberg, JE Jaspers, A Kersbergen, E van der Burg, AOH Nygren, ...
Proceedings of the National Academy of Sciences 105 (44), 17079-17084, 2008
11492008
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
Y Pommier, MJ O’Connor, J De Bono
Science translational medicine 8 (362), 362ps17-362ps17, 2016
7202016
4-[3-(4-Cyclopropanecarbonylpiperazine-1-carbonyl)-4-fluorobenzyl]-2H-phthalazin-1-one: A Novel Bioavailable Inhibitor of Poly(ADP-ribose) Polymerase-1
KA Menear, C Adcock, R Boulter, X Cockcroft, L Copsey, A Cranston, ...
Journal of medicinal chemistry 51 (20), 6581-6591, 2008
6652008
Loss of 53BP1 Causes PARP Inhibitor Resistance in Brca1-Mutated Mouse Mammary Tumors
JE Jaspers, A Kersbergen, U Boon, W Sol, L Van Deemter, SA Zander, ...
Cancer discovery 3 (1), 68-81, 2013
5582013
The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300
H Zimmermann, R Degenkolbe, HU Bernard, MJ O’Connor
Journal of virology 73 (8), 6209-6219, 1999
4581999
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
SE Golding, E Rosenberg, N Valerie, I Hussaini, M Frigerio, XF Cockcroft, ...
Molecular cancer therapeutics 8 (10), 2894-2902, 2009
4172009
Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin
B Evers, R Drost, E Schut, M de Bruin, E van der Burg, PWB Derksen, ...
Clinical Cancer Research 14 (12), 3916-3925, 2008
4052008
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
H Dev, TWW Chiang, C Lescale, I de Krijger, AG Martin, D Pilger, ...
Nature cell biology 20 (8), 954-965, 2018
4022018
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen, P Masterson, MJ O'Connor, SP Jackson
Cell 123 (6), 1065-1078, 2005
3972005
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
C Cruz, M Castroviejo-Bermejo, S Gutiérrez-Enríquez, A Llop-Guevara, ...
Annals of Oncology 29 (5), 1203-1210, 2018
3832018
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition
PM Krawczyk, B Eppink, J Essers, J Stap, H Rodermond, H Odijk, ...
Proceedings of the National Academy of Sciences 108 (24), 9851-9856, 2011
3802011
PARP Inhibitors: Extending Benefit Beyond BRCA-Mutant Cancers
PG Pilié, CM Gay, LA Byers, MJ O'Connor, TA Yap
Clinical Cancer Research 25 (13), 3759-3771, 2019
3242019
The overexpression of specialized DNA polymerases in cancer
MR Albertella, A Lau, MJ O’Connor
DNA repair 4 (5), 583-593, 2005
3122005
A role for polymerase η in the cellular tolerance to cisplatin-induced damage
MR Albertella, CM Green, AR Lehmann, MJ O'Connor
Cancer research 65 (21), 9799-9806, 2005
2922005
AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
JHL Fok, A Ramos-Montoya, M Vazquez-Chantada, PWG Wijnhoven, ...
Nature communications 10 (1), 5065, 2019
2752019
BRD4 inhibition is synthetic lethal with PARP inhibitors through the induction of homologous recombination deficiency
C Sun, J Yin, Y Fang, J Chen, KJ Jeong, X Chen, CP Vellano, Z Ju, ...
Cancer cell 33 (3), 401-416. e8, 2018
2752018
Randomized, double-blind phase II trial with prospective classification by ATM protein level to evaluate the efficacy and tolerability of olaparib plus paclitaxel in patients …
YJ Bang, SA Im, KW Lee, JY Cho, EK Song, KH Lee, YH Kim, JO Park, ...
Journal of clinical oncology 33 (33), 3858-3865, 2015
2742015
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Artículos 1–20