Todd Golde
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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction
S Oddo, A Caccamo, JD Shepherd, MP Murphy, TE Golde, R Kayed, ...
Neuron 39 (3), 409-421, 2003
An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp717) Mutants
N Suzuki, TT Cheung, XD Cai, A Odaka, L Otvos Jr, C Eckman, TE Golde, ...
Science 264 (5163), 1336-1340, 1994
Production of the Alzheimer amyloid β protein by normal proteolytic processing
M Shoji, TE Golde, J Ghiso, TT Cheung, S Estus, LM Shaffer, XD Cai, ...
Science 258 (5079), 126-129, 1992
A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity
S Weggen, JL Eriksen, P Das, SA Sagi, R Wang, CU Pietrzik, KA Findlay, ...
Nature 414 (6860), 212-216, 2001
Release of excess amyloid β protein from a mutant amyloid β protein precursor
XD Cai, TE Golde, SG Younkin
Science 259 (5094), 514-516, 1993
γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
CY Ni, MP Murphy, TE Golde, G Carpenter
Science 294 (5549), 2179-2181, 2001
The secretases: enzymes with therapeutic potential in Alzheimer disease
B De Strooper, R Vassar, T Golde
Nature reviews neurology 6 (2), 99-107, 2010
Processing of the amyloid protein precursor to potentially amyloidogenic derivatives
TE Golde, S Estus, LH Younkin, DJ Selkoe, SG Younkin
Science 255 (5045), 728-730, 1992
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
NSAIDs and enantiomers of flurbiprofen target γ-secretase and lower Aβ42 in vivo
JL Eriksen, SA Sagi, TE Smith, S Weggen, P Das, DC McLendon, ...
The Journal of clinical investigation 112 (3), 440-449, 2003
Aβ42 is essential for parenchymal and vascular amyloid deposition in mice
E McGowan, F Pickford, J Kim, L Onstead, J Eriksen, C Yu, L Skipper, ...
Neuron 47 (2), 191-199, 2005
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ...
Nature medicine 26 (5), 769-780, 2020
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
YJ Zhang, YF Xu, C Cook, TF Gendron, P Roettges, CD Link, WL Lin, ...
Proceedings of the National Academy of Sciences 106 (18), 7607-7612, 2009
Cholesterol-dependent γ-secretase activity in buoyant cholesterol-rich membrane microdomains
S Wahrle, P Das, AC Nyborg, C McLendon, M Shoji, T Kawarabayashi, ...
Neurobiology of disease 9 (1), 11-23, 2002
Expression of β amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR
TE Golde, S Estus, M Usiak, LH Younkin, SG Younkin
Neuron 4 (2), 253-267, 1990
Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor
S Estus, TE Golde, T Kunishita, D Blades, D Lowery, M Eisen, M Usiak, ...
Science 255 (5045), 726-728, 1992
Targeting Notch to target cancer stem cells
A Pannuti, K Foreman, P Rizzo, C Osipo, T Golde, B Osborne, L Miele
Clinical cancer research 16 (12), 3141-3152, 2010
Animal models of neurodegenerative diseases
TM Dawson, TE Golde, C Lagier-Tourenne
Nature neuroscience 21 (10), 1370-1379, 2018
Anti-Aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
TE Golde, LS Schneider, EH Koo
Neuron 69 (2), 203-213, 2011
Rational targeting of Notch signaling in cancer
P Rizzo, C Osipo, K Foreman, T Golde, B Osborne, L Miele
Oncogene 27 (38), 5124-5131, 2008
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Articles 1–20