Shin-ichiro Imai
Shin-ichiro Imai
Washington University School of Medicine
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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
SI Imai, CM Armstrong, M Kaeberlein, L Guarente
Nature 403 (6771), 795-800, 2000
hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase
H Vaziri, SK Dessain, EN Eaton, SI Imai, RA Frye, TK Pandita, L Guarente, ...
Cell 107 (2), 149-159, 2001
Negative control of p53 by Sir2α promotes cell survival under stress
J Luo, AY Nikolaev, S Imai, D Chen, F Su, A Shiloh, L Guarente, W Gu
Cell 107 (2), 137-148, 2001
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
JR Revollo, AA Grimm, S Imai
Journal of Biological Chemistry 279 (49), 50754-50763, 2004
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis
KM Ramsey, J Yoshino, CS Brace, D Abrassart, Y Kobayashi, B Marcheva, ...
Science 324 (5927), 651-654, 2009
Nampt/PBEF/visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
JR Revollo, A Körner, KF Mills, A Satoh, T Wang, A Garten, B Dasgupta, ...
Cell metabolism 6 (5), 363-375, 2007
Nicotinamide mononucleotide, a key NAD+ intermediate, treats the pathophysiology of diet-and age-induced diabetes in mice
J Yoshino, KF Mills, MJ Yoon, S Imai
Cell metabolism 14 (4), 528-536, 2011
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
KA Moynihan, AA Grimm, MM Plueger, E Bernal-Mizrachi, E Ford, ...
Cell metabolism 2 (2), 105-117, 2005
NAD+ and sirtuins in aging and disease
S Imai, L Guarente
Trends in cell biology 24 (8), 464-471, 2014
Sirt1 extends life span and delays aging in mice through the regulation of Nk2 homeobox 1 in the DMH and LH
A Satoh, CS Brace, N Rensing, P Cliften, DF Wozniak, ED Herzog, ...
Cell metabolism 18 (3), 416-430, 2013
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
S Imai, L Guarente
Trends in pharmacological sciences 31 (5), 212-220, 2010
Nampt: linking NAD biology, metabolism and cancer
A Garten, S Petzold, A Körner, S Imai, W Kiess
Trends in Endocrinology & Metabolism 20 (3), 130-138, 2009
Poly (ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2α deacetylase activity
JB Pillai, A Isbatan, S Imai, MP Gupta
Journal of Biological Chemistry 280 (52), 43121-43130, 2005
Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
J Yoshino, C Conte, L Fontana, B Mittendorfer, S Imai, KB Schechtman, ...
Cell metabolism 16 (5), 658-664, 2012
Silent information regulator 2α, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
RR Alcendor, LA Kirshenbaum, S Imai, SF Vatner, J Sadoshima
Circulation research 95 (10), 971-980, 2004
The dynamic regulation of NAD metabolism in mitochondria
LR Stein, S Imai
Trends in Endocrinology & Metabolism 23 (9), 420-428, 2012
The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt/PBEF/visfatin in mammals
JR Revollo, AA Grimm, S Imai
Current opinion in gastroenterology 23 (2), 164-170, 2007
Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
KM Ramsey, KF Mills, A Satoh, S Imai
Aging cell 7 (1), 78-88, 2008
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme
T Wang, X Zhang, P Bheda, JR Revollo, S Imai, C Wolberger
Nature structural & molecular biology 13 (7), 661-662, 2006
Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice
KF Mills, S Yoshida, LR Stein, A Grozio, S Kubota, Y Sasaki, P Redpath, ...
Cell metabolism 24 (6), 795-806, 2016
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