| Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099 X Sun, Y Ren, S Gunawan, P Teng, Z Chen, HR Lawrence, J Cai, ... Leukemia 32 (5), 1246-1249, 2018 | 65 | 2018 |
| Synthesis of tetrazolo-fused benzodiazepines and benzodiazepinones by a two-step protocol using an Ugi-azide reaction for initial diversity generation S Gunawan, M Ayaz, F De Moliner, B Frett, C Kaiser, N Patrick, Z Xu, ... Tetrahedron 68 (27-28), 5606-5611, 2012 | 61 | 2012 |
| Bifunctional building blocks in the Ugi-azide condensation reaction: a general strategy toward exploration of new molecular diversity S Gunawan, C Hulme Organic & biomolecular chemistry 11 (36), 6036-6046, 2013 | 58 | 2013 |
| Structural insights into JAK2 inhibition by ruxolitinib, fedratinib, and derivatives thereof RR Davis, B Li, SY Yun, A Chan, P Nareddy, S Gunawan, M Ayaz, ... Journal of medicinal chemistry 64 (4), 2228-2241, 2021 | 55 | 2021 |
| Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles S Gunawan, J Petit, C Hulme ACS Combinatorial Science 14 (3), 160-163, 2012 | 51 | 2012 |
| Potent dual BET bromodomain-kinase inhibitors as value-added multitargeted chemical probes and cancer therapeutics SW Ember, QT Lambert, N Berndt, S Gunawan, M Ayaz, M Tauro, JY Zhu, ... Molecular cancer therapeutics 16 (6), 1054-1067, 2017 | 48 | 2017 |
| Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon AA Akuffo, AY Alontaga, R Metcalf, MS Beatty, A Becker, JM McDaniel, ... Journal of Biological Chemistry 293 (16), 6187-6200, 2018 | 43 | 2018 |
| Targeting Aurora kinase A and JAK2 prevents GVHD while maintaining Treg and antitumor CTL function BC Betts, A Veerapathran, J Pidala, H Yang, P Horna, K Walton, CL Cubitt, ... Science translational medicine 9 (372), eaai8269, 2017 | 41 | 2017 |
| Targeting the BRD4-HOXB13 coregulated transcriptional networks with bromodomain-kinase inhibitors to suppress metastatic castration-resistant prostate cancer N Nerlakanti, J Yao, DT Nguyen, AK Patel, AM Eroshkin, HR Lawrence, ... Molecular cancer therapeutics 17 (12), 2796-2810, 2018 | 30 | 2018 |
| Concise route to a series of novel 3-(tetrazol-5-yl) quinoxalin-2 (1H)-ones S Gunawan, G Nichol, C Hulme Tetrahedron letters 53 (13), 1664-1667, 2012 | 30 | 2012 |
| Concise preparation of novel tricyclic chemotypes: fused hydantoin–benzodiazepines S Gunawan, GS Nichol, S Chappeta, J Dietrich, C Hulme Tetrahedron letters 51 (36), 4689-4692, 2010 | 25 | 2010 |
| Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade S Gunawan, C Hulme Tetrahedron letters 54 (33), 4467-4470, 2013 | 20 | 2013 |
| Synthesis of peptidomimetics, δ-and-lactam tetrazoles S Gunawan, K Keck, A Laetsch, C Hulme Molecular diversity 16 (3), 601-606, 2012 | 18 | 2012 |
| Differential BET bromodomain inhibition by dihydropteridinone and pyrimidodiazepinone kinase inhibitors RM Karim, MJ Bikowitz, A Chan, JY Zhu, D Grassie, A Becker, N Berndt, ... Journal of medicinal chemistry 64 (21), 15772-15786, 2021 | 12 | 2021 |
| Efficient synthesis of indole derivatives containing the tetrazole moeity utilizing an Ugi-Azide post-transformation strategy A Nikbakht, S Balalaie, F Baghestani, F Rominger Synlett 29 (14), 1892-1896, 2018 | 10 | 2018 |
| Mutation selectivity of the allosteric SHP2 inhibitor SHP099 X Sun, Y Ren, S Gunawan, P Teng, Z Chen, HR Lawrence, J Cai, ... Cancer Research 78 (13_Supplement), 4879-4879, 2018 | 2 | 2018 |
| 2-Butyl-11-phenyl-5, 10-dihydro-1H-benzo [e] imidazo [1, 5-a][1, 4] diazepine-1, 3 (2H)-dione GS Nichol, S Gunawan, J Dietrich, C Hulme Acta Crystallographica Section E: Structure Reports Online 66 (3), o625-o625, 2010 | 2 | 2010 |
| Intracellular protein degradation of BRD4 by dBET1 reveals conserved in vivo cereblon function in human and mouse T-cells AA Akuffo, A Alontaga, R Metclaf, MS Beatty, J McDaniel, S Gunawan, ... The Journal of Immunology 198 (1_Supplement), 52.18-52.18, 2017 | 1 | 2017 |
| Targeting the acetyl-lysine binding site of BRD4 with dual nanomolar BET-JAK2 inhibitors: A new anticancer therapeutic strategy S Gunawan, A Muhammad, SWJ Ember, JY Zhu, RA Jacobsen, N Berndt, ... Cancer Research 75 (15_Supplement), 3643-3643, 2015 | 1 | 2015 |
| 2-Propyl 3, 3-dibromo-2-hydroxypyrrolidine-1-carboxylate GS Nichol, S Gunawan, Z Xu, J Dietrich, C Hulme Acta Crystallographica Section E: Structure Reports Online 66 (3), o597-o597, 2010 | 1 | 2010 |
Christopher HulmeProfessor Drug Discovery/Medicinal Chemistry, University of ArizonaDirección de correo verificada de pharmacy.arizona.edu
